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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MECLOFENAMATE
| MECLOFENAMATE | MUSCULO-SKELETAL | ORAL | Cmax 16.2 MICROMOLAR Tmax 1.25 HOUR VD 23.3 LITER PPB 99 PERCENT Cl 12.3 LITER / HOUR HT 1.3 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 LEUKOCYTE 5-LIPOXYGENASE PROSTAGLANDIN G/H SYNTHASE 2 PDB 5IKQ (THE STRUCTURE OF MECLOFENAMIC ACID BOUND TO HUMAN CYCLOOXYGENASE-2) LIGAND CODE = JMS (link to the list of PDB complexes) Download experimental 3D coordinates of JMS with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
