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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| THIAMINE
| THIAMINE | NATURAL MOLECULE (link) METABOLISM | INJECTION INTRAVENOUS | Cmax 385 NANOMOLAR (PMID22305197) Tmax 4.14 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | PDB 3MYU (MYCOPLASMA GENITALIUM MG289) LIGAND CODE = VIB (link to the list of PDB complexes) Download experimental 3D coordinates of VIB with added hydrogens | Heat shock protein HSP 90-alpha UNIPROT P07900 HSP90AA1 more at DrugCentral | EMA | |||
