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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SCOPOLAMINE
| SCOPOLAMINE | NATURAL MOLECULE (link)
METABOLISM | TRANSDERMAL | Cmax 906 NANOMOLAR (PMID2762223) Tmax 4 HOUR F 29.4 PERCENT VD 201.5 LITER (65 KILOGRAM) PPB 10 PERCENT (PMID9725548) Cl 62.4 LITER / HOUR (65 KILOGRAM) HT 9.5 HOUR | MUSCARINIC ACETYLCHOLINE RECEPTOR PDB 8CVD (STRUCTURE OF HYOSCYAMINE 6-BETA HYDROXYLASE IN COMPLEX WITH IRON, SUCCINATE, AND SCOPOLAMINE) LIGAND CODE = OW0 (link to the list of PDB complexes) Download experimental 3D coordinates of OW0 with added hydrogens | Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1 more at DrugCentral | EMA | |||
