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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DINOPROSTONE

DINOPROSTONE


ATC G02AD02

GENITO
PROSTAGLANDIN
OXYTOCIC
NATURALLY OCCURRING FORM OF PROSTAGLANDIN E2 (PGE2)

VAGINAL ENDOCERVICAL

Cmax 1.23 NANOMOLAR

Tmax 0.62 HOUR

HT 0.06 HOUR

SOLUBILITY IN WATER 130 MILLIGRAM / 100 MILLILITER

PROSTAGLANDIN E2 RECEPTOR EP2

PDB 3WFH (CRYSTAL STRUCTURE OF ANTI-PROSTAGLANDIN E2 FAB FRAGMENT PGE2 COMPLEX)

LIGAND CODE = P2E (link to the list of PDB complexes)

Download experimental 3D coordinates of P2E with added hydrogens

Prostaglandin E2 receptor EP1 subtype UNIPROT P34995 PTGER1 -- Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3

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