| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TOLMETIN
| TOLMETIN | MUSCULO-SKELETAL | ORAL | Cmax 155 MICROMOLAR (400 MILLIGRAM ORAL DOSE) Tmax 0.75 HOUR F 100 PERCENT SOLUBILITY FREELY SOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 3S3G (CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH TOLMETIN) LIGAND CODE = TLT (link to the list of PDB complexes) Download experimental 3D coordinates of TLT with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
