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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MOMETASONE FUROATE (has an active metabolite)
| MOMETASONE FUROATE |
METABOLISM | TOPICAL NASAL INHALATION IMPLANTATION | Cmax 218.8 PICOMOLAR Tmax 1.75 HOUR VD 152 LITER PPB 98.5 PERCENT Cl 48.7 LITER / HOUR (65 KILOGRAM) HT 5.8 HOUR SOLUBILITY INSOLUBLE IN WATER | GLUCOCORTICOID RECEPTOR PDB 4P6W (CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN) LIGAND CODE = MOF (link to the list of PDB complexes) Download experimental 3D coordinates of MOF with added hydrogens | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
