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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MEBENDAZOLE

MEBENDAZOLE


ATC P02CA01
ATC P02CA51

ANTIPARASITIC
ANTHELMINTIC
ANTINEMATODAL AGENTS
INHIBITS THE FORMATION OF THE WORMS' MICROTUBULES

ORAL

VD 78 LITER (65 KILOGRAM)

PPB 91 PERCENT

Cl 58.5 LITER / HOUR (65 KILOGRAM)

HT 1.1 HOUR

SOLUBILITY LESS THAN 0.05 PERCENT SOLUBLE IN WATER

TUBULIN

PDB 7OGN (CRYSTAL STRUCTURE OF T2R-TTL -MEBENDAZOLE COMPLEX)

LIGAND CODE = V95 (link to the list of PDB complexes)

Download experimental 3D coordinates of V95 with added hydrogens

Tubulin UNIPROT C4PKY4 -- Tubulin UNIPROT F1L005

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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