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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRAZOSIN
| PRAZOSIN | CARDIOVASCULAR | ORAL | Tmax 3 HOUR F 90 PERCENT VD 47 LITER (65 KILOGRAM) PPB 94 PERCENT Cl 18.3 LITER / HOUR (65 KILOGRAM) HT 2.5 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | ALPHA-1A ADRENERGIC RECEPTOR ALPHA-1B ADRENERGIC RECEPTOR ALPHA-1D ADRENERGIC RECEPTOR PDB 3OWX (X-RAY STRUCTURAL STUDY OF QUINONE REDUCTASE II INHIBITION BY COMPOUNDS WITH MICROMOLAR TO NANOMOLAR RANGE IC50 VALUES) LIGAND CODE = XRA (link to the list of PDB complexes) Download experimental 3D coordinates of XRA with added hydrogens | Alpha-1A adrenergic receptor UNIPROT P35348 ADRA1A -- Alpha-1D adrenergic receptor UNIPROT P25100 ADRA1D more at DrugCentral | EMA | |||
