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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PILOCARPINE
| PILOCARPINE | NATURAL MOLECULE (link)
NERVOUS SYSTEM | OPHTHALMIC ORAL | Cmax 197 NANOMOLAR Tmax 0.85 HOUR PPB 0 PERCENT HT 1.35 HOUR SOLUBILITY SOLUBLE IN WATER | MUSCARINIC ACETYLCHOLINE RECEPTOR M1 MUSCARINIC ACETYLCHOLINE RECEPTOR M2 PDB 3T3R (HUMAN CYTOCHROME P450 2A6 IN COMPLEX WITH PILOCARPINE) LIGAND CODE = 9PL (link to the list of PDB complexes) Download experimental 3D coordinates of 9PL with added hydrogens | Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3 more at DrugCentral | EMA | |||
