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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRETINOIN

TRETINOIN


ATC D10AD01
ATC L01XF01
ATC D10AD51

DERMATOLOGICALS
KERATOLYTIC
ANTINEOPLASTIC AGENTS
RETINOIC ACID RECEPTOR (RAR) AGONIST
TREATMENT OF ACNE
ENDOGENOUS RETINOID METABOLITE OF VITAMIN A
INDUCES DIFFERENTIATION AND INHIBITS PROLIFERATION
INDUCES ITS OWN METABOLISM

TOPICAL ORAL

Cmax 1.31 MICROMOLAR

Tmax 1.5 HOUR

PPB 95 PERCENT

HT 1.25 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

RETINOIC ACID RECEPTOR (RAR)
CRABP I
CRABP II

PDB 3CWK (CRYSTAL STRUCTURE OF THE R132K:Y134F:R111L:T54V:L121E MUTANT OF CELLULAR RETINOIC ACID BINDING PROTEIN TYPE II IN COMPLEX WITH ALL-TRANS-RETINOIC ACID AT 1.57 ANGSTROMS RESOLUTION)

LIGAND CODE = REA_3CWK (link to the list of PDB complexes)

Download experimental 3D coordinates of REA_3CWK with added hydrogens

Retinoic acid receptor alpha UNIPROT P10276 RARA -- Retinoic acid receptor beta UNIPROT P10826 RARB

more at DrugCentral

EMA

ANSM (in French)

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BindingDB
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