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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESKETAMINE
| ESKETAMINE KETAMINE | NERVOUS SYSTEM | INJECTION NASAL | VD 188 LITER (65 KILOGRAM) PPB 53 PERCENT Cl 74 LITER / HOUR (65 KILOGRAM) HT 2.8 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | GLUTAMATE [NMDA] RECEPTOR AMPA RECEPTOR PDB 7SAC (S-(+)-KETAMINE BOUND GLUN1A-GLUN2B NMDA RECEPTORS AT 3.69 ANGSTROM RESOLUTION) LIGAND CODE = JC9 (link to the list of PDB complexes) Download experimental 3D coordinates of JC9 with added hydrogens | Glutamate NMDA receptor UNIPROT O15399 GRIN2D -- Glutamate receptor ionotropic AMPA UNIPROT P42261 GRIA1 more at DrugCentral | EMA | |||
