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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NALOXONE

NALOXONE


ATC N02AA53
ATC A06AH04
ATC V03AB15
ATC N02AA55
ATC N02AD51
ATC N02AX51

VARIOUS
ALKALOID
NARCOTIC ANTAGONIST
ANTINARCOTIC AGENTS
DEPRESSANTS
OPIATE ANTAGONISTS
RELIEF OF MODERATE TO SEVERE PAIN
TREATMENT OF OPIOID DEPENDANCE

INJECTION ORAL SUBLINGUAL BUCCAL INTRAMUSCULAR SUBCUTANEOUS NASAL

Cmax 0.85 NANOMOLAR

Tmax 0.81 HOUR

VD 110.5 LITER (65 KILOGRAM)

PPB 45 PERCENT

Cl 89.7 LITER / HOUR (65 KILOGRAM)

HT 6.25 HOUR

SOLUBILITY SOLUBLE IN WATER

MU-TYPE OPIOID RECEPTOR

Mu-type opioid receptor UNIPROT P35372 OPRM1

more at DrugCentral

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