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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CARBAMAZEPINE (has an active metabolite)
| CARBAMAZEPINE | NERVOUS SYSTEM | ORAL INTRAVENOUS | Cmax 8 MICROMOLAR Tmax 19 HOUR F 89 PERCENT VD 74.7 LITER (65 KILOGRAM) PPB 76 PERCENT Cl 4.8 LITER / HOUR HT 37.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | VOLTAGE-GATED SODIUM CHANNELS PDB 6TFB (CARBAMAZEPINE BINDS FRIZZLED8) LIGAND CODE = N6W (link to the list of PDB complexes) Download experimental 3D coordinates of N6W with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A more at DrugCentral | EMA | |||
