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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ETHAMBUTOL
| ETHAMBUTOL |
ANTIINFECTIVES | ORAL | Cmax 17.1 MICROMOLAR Tmax 3 HOUR VD 110.5 LITER (65 KILOGRAM) PPB 82 PERCENT Cl 39 LITER / HOUR (65 KILOGRAM) HT 3.1 HOUR | ARABINOSYLTRANSFERASES (PMID19596878) PDB 5NR3 (HUMAN DNMT3B PWWP DOMAIN IN COMPLEX WITH ETHAMBUTOL) LIGAND CODE = 95E (link to the list of PDB complexes) Download experimental 3D coordinates of 95E with added hydrogens | Probable arabinosyltransferase A UNIPROT P9WNL9 embA more at DrugCentral | EMA | |||
