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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIHYDROERGOTAMINE
| DIHYDROERGOTAMINE | NERVOUS SYSTEM | INJECTION NASAL | Cmax 7.6 NANOMOLAR (PMID8841149) Tmax 0.38 HOUR VD 800 LITER PPB 93 PERCENT Cl 90 LITER / HOUR HT 9 HOUR | 5-HYDROXYTRYPTAMINE 1 RECEPTOR 5-HYDROXYTRYPTAMINE 2 RECEPTOR ALPHA ADRENERGIC RECEPTOR DOPAMINE RECEPTOR PDB 4IAQ (CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET)) LIGAND CODE = 2GM (link to the list of PDB complexes) Download experimental 3D coordinates of 2GM with added hydrogens | 5-hydroxytryptamine receptor 1D UNIPROT P28221 HTR1D more at DrugCentral | EMA | |||
