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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| INDOMETHACIN
| INDOMETHACIN |
MUSCULO-SKELETAL SYSTEM | ORAL RECTAL INJECTION | Cmax 5.6 MICROMOLAR Tmax 2 HOUR F 100 PERCENT VD 6.24 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 5.07 LITER / HOUR (65 KILOGRAM) HT 4.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 4IKI (CRYSTAL STRUCTURE OF WILD-TYPE HUMAN TRANSTHYRETIN IN COMPLEX WITH INDOMETHACIN) LIGAND CODE = IMN (link to the list of PDB complexes) Download experimental 3D coordinates of IMN with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
