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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMANTADINE
| AMANTADINE | NERVOUS SYSTEM | ORAL | Cmax 1.45 MICROMOLAR Tmax 3.3 HOUR VD 357 LITER (65 KILOGRAM) PPB 67 PERCENT Cl 18.2 LITER / HOUR (65 KILOGRAM) HT 17 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | (PUTATIVE) NICOTINIC ACETYLCHOLINE RECEPTOR PDB 2KQT (SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE) LIGAND CODE = 308 (link to the list of PDB complexes) Download experimental 3D coordinates of 308 with added hydrogens | Matrix protein 2 UNIPROT P63231 M -- Glutamate NMDA receptor UNIPROT O15399 GRIN2D more at DrugCentral | EMA | |||
