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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MEFENAMIC ACID
| MEFENAMIC ACID | MUSCULO-SKELETAL SYSTEM | ORAL | Cmax 62.2 MICROMOLAR Tmax 2 HOUR VD 68.9 LITER (65 KILOGRAM) PPB 90 PERCENT Cl 21.2 LITER / HOUR HT 3 HOUR SOLUBILITY 0.004 PERCENT IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 4JQA (AKR1C2 COMPLEX WITH MEFENAMIC ACID) LIGAND CODE = ID8 (link to the list of PDB complexes) Download experimental 3D coordinates of ID8 with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
