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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NORTRIPTYLINE
| NORTRIPTYLINE | NERVOUS SYSTEM | ORAL | Cmax 241 NANOMOLAR (PMID19444001) Tmax 4 HOUR VD 1430 LITER (65 KILOGRAM) PPB 88 PERCENT Cl 39 LITER / HOUR (65 KILOGRAM) HT 30 HOUR | NORADRENALINE TRANSPORTER SEROTONIN TRANSPORTER PDB 4M48 (X-RAY STRUCTURE OF DOPAMINE TRANSPORTER ELUCIDATES ANTIDEPRESSANT MECHANISM) LIGAND CODE = 21B (link to the list of PDB complexes) Download experimental 3D coordinates of 21B with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
