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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VINCRISTINE
| VINCRISTINE | ANTINEOPLASTIC | INJECTION INTRAVENOUS | VD 156 LITER (65 KILOGRAM) PPB 60 PERCENT Cl 7.8 LITER / HOUR (65 KILOGRAM) HT 87 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | TUBULIN BETA CHAIN PDB 7A69 (NANODISC RECONSTITUTED HUMAN ABCB1 IN COMPLEX WITH MRK16 FAB AND VINCRISTINE) LIGAND CODE = R1Q (link to the list of PDB complexes) Download experimental 3D coordinates of R1Q with added hydrogens | Tubulin beta UNIPROT P07437 TUBB more at DrugCentral | EMA | |||
