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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DESIPRAMINE
| DESIPRAMINE | NERVOUS SYSTEM | ORAL | VD 975 LITER (65 KILOGRAM) PPB 84 PERCENT Cl 42.9 LITER / HOUR (65 KILOGRAM) HT 22 HOUR | NORADRENALINE TRANSPORTER SEROTONIN TRANSPORTER PDB 2QB4 (CRYSTAL STRUCTURE ANALYSIS OF LEUT COMPLEXED WITH L-LEUCINE, SODIUM AND DESIPRAMINE) LIGAND CODE = DSM (link to the list of PDB complexes) Download experimental 3D coordinates of DSM with added hydrogens | Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2 more at DrugCentral | EMA | |||
