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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIAZEPAM (has an active metabolite)

DIAZEPAM


ATC N05BA01

NERVOUS SYSTEM
ANXIOLYTIC
ANESTHETICS
ANTICONVULSANTS
ANTIEMETICS
GABA AGONIST
HYPNOTICS AND SEDATIVES
MUSCLE RELAXANTS, CENTRAL
BENZODIAZEPINE

ORAL INJECTION RECTAL NASAL BUCCAL

Tmax 1.25 HOUR

F 90 PERCENT

VD 58.5 LITER (65 KILOGRAM)

PPB 98 PERCENT

Cl 1.5 LITER / HOUR

HT 46 HOUR

SOLUBILITY INSOLUBLE IN WATER

GAMMA-AMINOBUTYRIC-ACID RECEPTOR

PDB 2BXF (HUMAN SERUM ALBUMIN COMPLEXED WITH DIAZEPAM)

LIGAND CODE = DZP (link to the list of PDB complexes)

Download experimental 3D coordinates of DZP with added hydrogens

GABA A receptor alpha-5,beta-2,gamma-3 UNIPROT P31644 GABRA5 -- GABA-A receptor alpha-1,beta-2,gamma-2 UNIPROT P14867 GABRA1

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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