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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRIAMTERENE
| TRIAMTERENE | CARDIOVASCULAR | ORAL | Cmax 183.3 NANOMOLAR Tmax 1.1 HOUR VD 845 LITER (65 KILOGRAM) PPB 58 PERCENT Cl 245.7 LITER / HOUR (65 KILOGRAM) HT 4.3 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PDB 3JQ7 (CRYSTAL STRUCTURE OF PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN TERNARY COMPLEX WITH COFACTOR (NADP+) AND INHIBITOR 6-PHENYLPTERIDINE-2,4,7-TRIAMINE (DX2)) LIGAND CODE = DX2 (link to the list of PDB complexes) Download experimental 3D coordinates of DX2 with added hydrogens | Amiloride-sensitive sodium channel, ENaC UNIPROT P37088 SCNN1A more at DrugCentral | EMA | |||
