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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
METYRAPONE

METYRAPONE


ATC V04CD01

VARIOUS
ANTIMETABOLITES
INHIBITOR OF ENDOGENOUS ADRENAL CORTICOSTEROID SYNTHESIS
REDUCE CORTISOL AND CORTICOSTERONE PRODUCTION BY INHIBITING THE 11-BETA-HYDROXYLATION REACTION IN THE ADRENAL CORTEX RESULTING IN AN INCREASE IN ADRENOCORTICOTROPIC HORMONE (ACTH) PRODUCTION BY THE PITUITARY
ALSO SUPPRESS BIOSYNTHESIS OF ALDOSTERONE
CYP11B1 INHIBITOR

ORAL

Cmax 32.3 MICROMOLAR

Tmax 1 HOUR

HT 1.9 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

CYTOCHROME P450 CYP11B1

PDB 1W0G (CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4)

LIGAND CODE = MYT (link to the list of PDB complexes)

Download experimental 3D coordinates of MYT with added hydrogens

Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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