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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DIPYRIDAMOLE
| DIPYRIDAMOLE | NATURAL MOLECULE (link) BLOOD | ORAL INJECTION | Cmax 3.92 MICROMOLAR Tmax 2 HOUR VD 92 LITER PPB 99 PERCENT Cl 4.6 LITER / HOUR (EQN) HT 13.6 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (LOGP=3.71) | PHOSPHODIESTERASE PDB 8I4A (CRYO-EM STRUCTURE OF DIPYRIDAMOLE-BOUND ABCC4) LIGAND CODE = H9F (link to the list of PDB complexes) Download experimental 3D coordinates of H9F with added hydrogens | cGMP-specific 3,5-cyclic phosphodiesterase UNIPROT O76074 PDE5A -- cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A UNIPROT Q9Y233 PDE10A more at DrugCentral | EMA | |||
