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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TRANYLCYPROMINE
| TRANYLCYPROMINE | NERVOUS SYSTEM | ORAL | Cmax 368.4 NANOMOLAR (PMID12959316) Tmax 1 HOUR (PMID3757407) VD 144.5 LITER (EQN) Cl 63.4 LITER / HOUR HT 1.58 HOUR | MONOAMINE OXIDASE MAO PDB 3MDR (TRANYLCYPROMINE COMPLEX OF CYTOCHROME P450 46A1) LIGAND CODE = GJZ (link to the list of PDB complexes) Download experimental 3D coordinates of GJZ with added hydrogens | Amine oxidase flavin-containing B UNIPROT P27338 MAOB more at DrugCentral | EMA | |||
