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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SPIRONOLACTONE
| SPIRONOLACTONE | CARDIOVASCULAR | ORAL | Cmax 193.2 NANOMOLAR Tmax 2.6 HOUR PPB 90 PERCENT SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | MINERALOCORTICOID RECEPTOR PDB 3VHU (MINERALOCORTICOID RECEPTOR LIGAND-BINDING DOMAIN WITH SPIRONOLACTONE) LIGAND CODE = SNL (link to the list of PDB complexes) Download experimental 3D coordinates of SNL with added hydrogens | Mineralocorticoid receptor UNIPROT P08235 NR3C2 more at DrugCentral | EMA | |||
