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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDROCHLOROTHIAZIDE
| HYDROCHLOROTHIAZIDE |
CARDIOVASCULAR | ORAL | Cmax 454.2 NANOMOLAR Tmax 1.5 HOUR VD 370.5 LITER (65 KILOGRAM) PPB 67.9 PERCENT Cl 23 LITER / HOUR HT 4.5 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CARBONIC ANHYDRASE PDB 3IJX (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, HYDROCHLOROTHIAZIDE) LIGAND CODE = HCZ (link to the list of PDB complexes) Download experimental 3D coordinates of HCZ with added hydrogens | Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3 more at DrugCentral | EMA | |||
