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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHAZOLAMIDE
| METHAZOLAMIDE | SENSORY | ORAL | Cmax 45.3 MICROMOLAR Tmax 1.5 HOUR VD 20 LITER PPB 55 PERCENT Cl 0.99 LITER / HOUR (EQN) HT 14 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | CARBONIC ANHYDRASE PDB 3DAZ (USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES) LIGAND CODE = MZM (link to the list of PDB complexes) Download experimental 3D coordinates of MZM with added hydrogens | Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 more at DrugCentral | EMA | |||
