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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TUBOCURARINE DISCONTINUED

TUBOCURARINE


ATC M03AA02

MUSCULO-SKELETAL
ALKALOID
NEUROMUSCULAR NONDEPOLARIZING AGENTS
INTERFERES WITH NICOTINIC ACETYLCHOLINE RECEPTOR (ACHR)
SKELETAL MUSCLE RELAXANTS

INJECTION

VD 29.2 LITER (65 KILOGRAM)

PPB 42 PERCENT

Cl 13.2 LITER / HOUR (65 KILOGRAM)

HT 2 HOUR

5-HYDROXYTRYPTAMINE 3 RECEPTOR (PMID16723497)

PDB 3PMZ (CRYSTAL STRUCTURE OF THE COMPLEX OF ACETYLCHOLINE BINDING PROTEIN AND D-TUBOCURARINE)

LIGAND CODE = TUB (link to the list of PDB complexes)

Download experimental 3D coordinates of TUB with added hydrogens

Acetylcholine receptor UNIPROT P02708 CHRNA1

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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