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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IPTACOPAN
| IPTACOPAN | IMMUNOSUPPRESSANTS | ORAL | Tmax 2 HOUR VD 288 LITER PPB 84 PERCENT Cl 7.96 LITER / HOUR HT 25 HOUR | COMPLEMENT FACTOR B PDB 6RAV (COMPLEMENT FACTOR B PROTEASE DOMAIN IN COMPLEX WITH THE REVERSIBLE INHIBITOR 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID) LIGAND CODE = JGQ (link to the list of PDB complexes) Download experimental 3D coordinates of JGQ with added hydrogens | Complement factor B UNIPROT P00751 more at DrugCentral | EMA | |||
