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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CAPIVASERTIB

CAPIVASERTIB


ATC L01EX27

ANTINEOPLASTIC
TREATMENT OF BREAST CANCER
INHIBITOR OF SERINE/THREONINE KINASE AKT (AKT1, AKT2 AND AKT3)

ORAL

Cmax 3.2 MICROMOLAR

Tmax 1.5 HOUR

F 29 PERCENT

VD 1847 LITER

PPB 22 PERCENT

Cl 50 LITER / HOUR

HT 8.3 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE AT PH VALUES ABOVE 6.8

SERINE THREONINE KINASE AKT1 AKT2 AND AKT3

PDB 4GV1 (PKB ALPHA IN COMPLEX WITH AZD5363)

LIGAND CODE = 0XZ (link to the list of PDB complexes)

Download experimental 3D coordinates of 0XZ with added hydrogens

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more at DrugCentral

EMA

ANSM (in French)

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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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