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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GIVINOSTAT
| GIVINOSTAT | MUSCULO-SKELETAL SYSTEM | ORAL | Tmax 2.5 HOUR PPB 96 PERCENT HT 6 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | HISTONE DEACETYLASE PDB 6UOC (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 1 (CD1) K330L MUTANT COMPLEXED WITH GIVINOSTAT) LIGAND CODE = QCM (link to the list of PDB complexes) Download experimental 3D coordinates of QCM with added hydrogens | - more at DrugCentral | EMA | |||
