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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
QUIZARTINIB (has an active metabolite)

QUIZARTINIB


ATC L01EX11

ANTINEOPLASTIC
TREATMENT OF ACUTE MYELOID LEUKEMIA (AML)
TYROSINE KINASE FLT3 INHIBITOR
BIND TO THE ADENOSINE TRIPHOSPHATE (ATP) BINDING DOMAIN

ORAL

Cmax 249 NANOMOLAR

Tmax 4 HOUR

F 71 PERCENT

VD 275 LITER

PPB 99 PERCENT

Cl 2.23 LITER / HOUR

HT 81 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

TYROSINE KINASE FLT3

PDB 4XUF (CRYSTAL STRUCTURE OF THE FLT3 KINASE DOMAIN BOUND TO THE INHIBITOR QUIZARTINIB (AC220))

LIGAND CODE = P30 (link to the list of PDB complexes)

Download experimental 3D coordinates of P30 with added hydrogens

Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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