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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VADADUSTAT
| VADADUSTAT | BLOOD | ORAL | Tmax 2.5 HOUR PPB 99.5 PERCENT HT 9.2 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH) PDB 5OPC (FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND VADADUSTAT) LIGAND CODE = A1Z (link to the list of PDB complexes) Download experimental 3D coordinates of A1Z with added hydrogens | Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1 -- Egl nine homolog 2 UNIPROT Q96KS0 EGLN2 more at DrugCentral | EMA | |||
