PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)
Primary Target and PDB code of Protein-Drug complex
ANTINEOPLASTIC FOLATE RECEPTOR ALPHA (FRALPHA)-DIRECTED ANTIBODY MICROTUBULE INHIBITOR CONJUGATE ANTIBODY-DRUG CONJUGATE (ADC) DM4 IS A MAYTANSINE DERIVATIVE DM4 DISRUPTS THE MICROTUBULE NETWORK WITHIN THE CELL, RESULTING IN CELL CYCLE ARREST AND APOPTOTIC CELL DEATH TREATMENT OF ADULT PATIENTS WITH FR ALPHA POSITIVE, PLATINUM-RESISTANT EPITHELIAL OVARIAN, FALLOPIAN TUBE, OR PRIMARY PERITONEAL CANCER