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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DURLOBACTAM

DURLOBACTAM

ANTIINFECTIVES
A DIAZABICYCLOOCTANE BETA LACTAMASE INHIBITOR
TREATMENT OF HOSPITAL-ACQUIRED BACTERIAL PNEUMONIA AND VENTILATOR-ASSOCIATED BACTERIAL PNEUMONIA (HABP/VABP) CAUSED BY SUSCEPTIBLE ISOLATES OF ACINETOBACTER BAUMANNII-CALCOACETICUS COMPLEX

INTRAVENOUS

Cmax 105.3 MICROMOLAR

VD 30.3 LITER

PPB 10 PERCENT

Cl 9.96 LITER / HOUR

HT 2.52 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

BETA LACTAMASE

beta-lactamase UNIPROT S5MN77

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