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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SOTAGLIFLOZIN
| SOTAGLIFLOZIN | METABOLISM | ORAL | Tmax 2.1 HOUR F 25 PERCENT VD 9000 LITER PPB 93 PERCENT Cl 315 LITER / HOUR HT 28 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) SODIUM-GLUCOSE COTRANSPORTER 1 (SGLT1) PDB 8HG7 (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH SOTAGLIFLOZIN) LIGAND CODE = LFL (link to the list of PDB complexes) Download experimental 3D coordinates of LFL with added hydrogens | Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 -- Sodium,glucose cotransporter 1 UNIPROT P13866 SLC5A1 more at DrugCentral | EMA | |||
