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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PIRTOBRUTINIB

PIRTOBRUTINIB


ATC L01EL05

ANTINEOPLASTIC
BTK KINASE INHIBITOR
TREATMENT OF MANTLE CELL LYMPHOMA (MCL)

ORAL

Cmax 13.5 MICROMOLAR

Tmax 2 HOUR

F 85.5 PERCENT

VD 32.8 LITER

PPB 96 PERCENT

Cl 2.02 LITER / HOUR

HT 19 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

BTK KINASE

PDB 8FLL (CRYSTAL STRUCTURE OF BTK KINASE DOMAIN IN COMPLEX WITH PIRTOBRUTINIB)

LIGAND CODE = Y7W (link to the list of PDB complexes)

Download experimental 3D coordinates of Y7W with added hydrogens

Tyrosine-protein kinase BTK UNIPROT Q06187

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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