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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LENACAPAVIR
| LENACAPAVIR | ANTIINFECTIVES | SUBCUTANEOUS ORAL | Cmax 100.3 NANOMOLAR Tmax 5 HOUR F 8 PERCENT VD 19240 LITER PPB 98.5 PERCENT Cl 55 LITER / HOUR HT 264 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | GAG POLYPROTEIN PDB 7RHN (CO-CRYSTAL STRUCTURE OF Q67H MUTANT OF DISULFIDE STABILIZED HIV-1 CA HEXAMER AND LENACAPAVIR) LIGAND CODE = QNG (link to the list of PDB complexes) Download experimental 3D coordinates of QNG with added hydrogens | Gag polyprotein UNIPROT P12493 more at DrugCentral | EMA | |||
