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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OLUTASIDENIB
| OLUTASIDENIB | ANTINEOPLASTIC | ORAL | Cmax 10.1 MICROMOLAR Tmax 4 HOUR VD 319 LITER PPB 93 PERCENT Cl 4 LITER / HOUR HT 67 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | ISOCITRATE DEHYDROGENASE-1 (IDH1) PDB 6U4J (CRYSTAL STRUCTURE OF IDH1 R132H MUTANT IN COMPLEX WITH FT-2102) LIGAND CODE = PWV (link to the list of PDB complexes) Download experimental 3D coordinates of PWV with added hydrogens | Isocitrate dehydrogenase NADP cytoplasmic IDH1 UNIPROT O75874 IDH1 more at DrugCentral | EMA | |||
