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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MITAPIVAT

MITAPIVAT


ATC B06AX04

METABOLISM
TREATMENT OF HEMOLYTIC ANEMIA WITH PYRUVATE KINASE (PK) DEFICIENCY
PYRUVATE KINASE ACTIVATOR
BINDS THE PROTEIN TETRAMER

ORAL

Cmax 2.1 MICROMOLAR

Tmax 0.75 HOUR

F 73 PERCENT

VD 42.5 LITER

PPB 97.7 PERCENT

Cl 14.4 LITER / HOUR

HT 4 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

PYRUVATE KINASE

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