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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OTESECONAZOLE
| OTESECONAZOLE | ANTIINFECTIVES | ORAL | Cmax 5.3 MICROMOLAR Tmax 7.5 HOUR VD 423 LITER PPB 99.5 PERCENT HT 3312 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | STEROL 14-ALPHA DEMETHYLASE (CYP51) PDB 5TZ1 (CRYSTAL STRUCTURE OF STEROL 14-ALPHA DEMETHYLASE (CYP51) FROM CANDIDA ALBICANS IN COMPLEX WITH THE TETRAZOLE-BASED ANTIFUNGAL DRUG CANDIDATE VT1161 (VT1)) LIGAND CODE = VT1 (link to the list of PDB complexes) Download experimental 3D coordinates of VT1 with added hydrogens | Lanosterol 14-alpha demethylase UNIPROT P10613 more at DrugCentral | EMA | |||
