| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BELZUTIFAN
| BELZUTIFAN | ANTINEOPLASTIC | ORAL | Cmax 3.4 MICROMOLAR Tmax 1.5 HOUR VD 130 LITER PPB 45 PERCENT Cl 7.3 LITER / HOUR HT 14 HOUR SOLUBILITY INSOLUBLE IN WATER | HYPOXIA-INDUCIBLE FACTOR-2 ALPHA PDB 5T0T (CRYSTAL STRUCTURE OF PT2399 BOUND TO HIF2A-B, ARNT-B COMPLEX) LIGAND CODE = 72Q (link to the list of PDB complexes) Download experimental 3D coordinates of 72Q with added hydrogens | Endothelial PAS domain-containing protein 1 UNIPROT Q99814 more at DrugCentral | EMA | |||
