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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VONOPRAZAN
| VONOPRAZAN |
METABOLISM | ORAL | Cmax 73 NANOMOLAR Tmax 2.5 HOUR VD 1001 LITER PPB 86.5 PERCENT Cl 97.3 LITER / HOUR HT 7.1 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | POTASSIUM-TRANSPORTING ATPASE PDB 5YLU (CRYSTAL STRUCTURE OF THE GASTRIC PROTON PUMP COMPLEXED WITH VONOPRAZAN) LIGAND CODE = HKT (link to the list of PDB complexes) Download experimental 3D coordinates of HKT with added hydrogens | Potassium-transporting ATPase UNIPROT P20648 ATP4A more at DrugCentral | EMA | |||
