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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MAVACAMTEN
| MAVACAMTEN | CARDIOVASCULAR | ORAL | Tmax 1 HOUR F 85 PERCENT PPB 98 PERCENT HT 180 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER AT PH 2-10 | CARDIAC MYOSIN PDB 8QYR (BETA-CARDIAC MYOSIN MOTOR DOMAIN IN THE PRE-POWERSTROKE STATE COMPLEXED TO MAVACAMTEN) LIGAND CODE = XB2 (link to the list of PDB complexes) Download experimental 3D coordinates of XB2 with added hydrogens | Myosin-7 UNIPROT P12883 more at DrugCentral | EMA | |||
