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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DARIDOREXANT
| DARIDOREXANT | NERVOUS SYSTEM | ORAL | Tmax 1.5 HOUR F 62 PERCENT VD 31 LITER PPB 99.7 PERCENT HT 8 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | OREXIN-1 RECEPTOR (OX1R) OREXIN-2 RECEPTOR (OX2R) PDB 6TP3 (CRYSTAL STRUCTURE OF THE OREXIN-1 RECEPTOR IN COMPLEX WITH DARIDOREXANT) LIGAND CODE = NS2 (link to the list of PDB complexes) Download experimental 3D coordinates of NS2 with added hydrogens | Orexin Hypocretin receptor type 1 UNIPROT O43613 HCRTR1 -- Orexin receptor type 2 UNIPROT O43614 HCRTR2 more at DrugCentral | EMA | |||
