| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LEVOKETOCONAZOLE
| LEVOKETOCONAZOLE | GENITO | ORAL | Tmax 1.75 HOUR VD 36 LITER PPB 99.3 PERCENT HT 3.75 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER AT PH 2 | CYP11B1 CYP11A1 CYP17A1 PDB 3OZW (THE CRYSTAL STRUCTURE OF FLAVOHEMOGLOBIN FROM R. EUTROPHUS IN COMPLEX WITH KETOCONAZOLE) LIGAND CODE = KKK_3OZW (link to the list of PDB complexes) Download experimental 3D coordinates of KKK_3OZW with added hydrogens | Steroid 17-alpha-hydroxylase 17,20 lyase UNIPROT P05093 CYP17A1 -- Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1 more at DrugCentral | EMA | |||
