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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BRINCIDOFOVIR (has an active metabolite)

BRINCIDOFOVIR


ATC J05AB12

ANTIINFECTIVES
ORTHOPOXVIRUS NUCLEOTIDE ANALOG DNA POLYMERASE INHIBITOR
TREATMENT OF HUMAN SMALLPOX DISEASE
ANTIVARIOLA
METABOLIZED BY SPHINGOMYELINASE

ORAL

Cmax 854.5 NANOMOLAR

Tmax 3 HOUR

F 16.8 PERCENT

VD 1230 LITER

PPB 99.9 PERCENT

Cl 44.1 LITER / HOUR

HT 19.3 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

DNA POLYMERASE

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