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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTETROL
| ESTETROL | GENITO | ORAL | Cmax 58.8 NANOMOLAR Tmax 0.5 HOUR PPB 48 PERCENT HT 27 HOUR SOLUBILITY POORLY SOLUBLE IN WATER | ESTROGEN RECEPTOR PDB 3L03 (CRYSTAL STRUCTURE OF HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE AND ESTETROL) LIGAND CODE = 4OH (link to the list of PDB complexes) Download experimental 3D coordinates of 4OH with added hydrogens | Estrogen receptor UNIPROT P03372 ESR1 -- Estrogen receptor beta UNIPROT Q92731 ESR2 more at DrugCentral | EMA | |||
